DNA TEST OVERVIEW Personal Details Ordering Healthcare Professional Laboratory Info Name: DOB: Gender: Female Ethnicity: Hispanic Indication: Population Screening Received Date: Jun 21, 2012 Test Performed / Method - Genotyping by array-based evaluation of multiple molecular probes Specimen Source: Saliva Collected Date: Not provided *We tested your DNA for 3 complex health conditions. *Number of conditions tested will vary depending on ethnicity and gender. Each condition is placed into one of four risk categories. Your placement in these categories is determined by our proprietary algorithm using knowledge of your genotype together with published research about the risk associated with individual genotypes for that condition. Where possible we have used research in individuals of your stated ethnicity. Where there is no research concerning your ethnic group, we have used the best available research (usually Caucasian). The four categories are intended to represent the appropriate level of reaction based upon your genotype for the markers we have tested. Condition Name Condition Risk Population Risk * Asthma Learn More 11.2% Breast cancer Be Proactive 12.1% Systemic lupus erythematosus Learn More Unknown * Population risk is defined here as an estimate of the percentage of people in the general population who will develop the condition in their remaining lifetime. These estimates are taken from published research for individuals free of the condition in a specific population at a particular age and are not adjusted for individual results. Health Conditions - Asthma, Breast Cancer, and SLE (Content Provided By: Pathway Genomic. What We Tested and Your Results) These results are based on your reported ethnicity of: Hispanic HEALTH CONDITION - Asthma Gene/Locus1 SNP1 Your Genotype2 Odds Ratio3 Associated Allele2 Population Frequency4 Validated Marker5 PMID6 ORMDL3 rs7216389 T/C 1.62 T 56% Validated 19133921 HEALTH CONDITION - Breast cancer Gene/Locus1 SNP1 Your Genotype2 Odds Ratio3 Associated Allele2 Population Frequency4 Validated Marker5 PMID6 Intergenic_2q35 rs13387042 A/G 1.21 A 38% Preliminary 17529974 HEALTH CONDITION - Systemic lupus erythematosus Gene/Locus1 SNP1 Your Genotype2 Odds Ratio3 Associated Allele2 Population Frequency4 Validated Marker5 PMID6 ITGAM rs1143679 G/G 1 A 9% Validated 19129174 PTPN22 rs2476601 G/G 1 A 5% Validated 16868974 STAT4 rs7574865 T/G 1.62 T 40% Validated 18432273 DNA TEST OVERVIEW Glossary 1 - These are the gene and Single Nucleotide Polymorphism (SNP), also referred to as a marker, that were tested for this report. A SNP/ Marker is a specific variation in an individual's DNA sequence. 2 - Your Genotype is the allele or base (A, T, G or C) composition found at the SNP/marker in your DNA and may contain the allele associated with the risk of the disease (Associated Allele). Two alleles (e.g. G/G) are shown because you inherit one copy from your mother and one copy from your father. 3 - The odds ratio is a measure of the likelihood that an event will occur in one group as compared to another. In genetics, the odds ratio measures the likelihood or risk that someone will get a disease/condition if they carry a specific genetic change. An odds ratio of 1 means the patient's observed genotype does not contain the risk associated allele. A patient with an odds ratio greater than 1 has a genotype that is associated with an increase in risk, while a patient with an odds ratio less than 1 has a genotype that is associated with a decrease in risk. 4 - Population Frequency is the percentage of people who have been found to have the Associated Allele in the Population Studied (Asian, Caucasian or African). 5 - Validated markers represent the highest quality genetic markers available, while Preliminary markers represent the latest in genetic research and have not met our high standards for validation. 6 - PubMed is a service managed by the National Library of Medicine that tracks more than 19 million citations for biomedical articles and scientific research. The Pubmed ID is used to identify each of those articles, and can be looked up at http://www.ncbi.nlm.nih.gov/pubmed.